Scott Bakula, as Quintin Mills, 1983
Christine Baranski, as Beverly Tucker, September 1983
Kelly Bishop, as Mrs. Markham, a woman who was having an affair with Reginald Love's accomplice, Bernie, January 13, 1987
Mark Blum, as Vinnie, a blackjack dealer at The Arena, November 13, 1980, December 10 & 22, 1980
Eugene Byrd, as Kyle, a friend of Derek Dane's, July 31, 1989 - April 23, 1990 [recur]
Thomas Calabro, as a Brava executive, who flirted with Amanda Cory, September 1, 1987
Gabrielle Carteris, as (1) Janice, July 1984, and (2) Tracy Julian, May 16 - September 1, 1988
Michael Cerveris, as Nathan, Vicky Hudson's date at Mary's Place, 1988
Justin Chambers, as Nick Hudson, May 16, 1995 - June 22, 1995
Patricia Clarkson, as (1) Sister Margaret, June 9, 1986, and (2) Marlena MacDonald, June 1987
Claudia Cohen, as Shana Barr, 1990
Frances Conroy, as Mary Lou, a museum secretary, November - December 1982
Chris Cooper, as Ed, a bartender in Dry Creek, Wyoming, 1985
Marcia Cross, as Tanya, Cass Winthrop's date, March 21 and 24, 1986
Kristin Davis, as Page, November 29 and 30, 1990
Megan Dodds, as Denise Lewis, December 10, 1996
Jeffrey Donovan, as Dwayne "Popper" Collins, November 3 - 17, 1997
Kathryn Erbe, as Ashley, a college friend of Josie Watts, November 15, 1988
Giancarlo Esposito, as Willie Armstrong, March 11-30, 1982
Morgan Freeman, as Roy Bingham, October 12, 1982 - May 14, 1984
Dan Futterman, as Alan Lottin, 5 episodes, August 1992
Gil Gerard, as Fred Warner, January 14, 1972. He was seen at the top of the scene exiting the law office. His one line: "Thank you, Mr. Randolph, Mr. Curtin."
Thomas Gibson, as Sam Fowler, temporary replacement, May 21 - June 19, 1990
Kelsey Grammer, as (1) a head paramedic, March 19, 1982, and (2) Dr. Canard, recurring, 1984
Michael Gross, as Randy, June 26 - July 20, 1981
Jackee Harry, as Lily Mason, March 3, 1983 - June 25, 1986
Melissa Joan Hart, as a roller-bladder in a location shot at Playland with Cass Winthrop and Kathleen McKinnon, April 22, 1986
Don Harvey, as Aces, a gang member who kidnapped and held Vicky Hudson hostage, July 1 - 21, 1986
Leslie Hendrix, as a reporter, December 27, 1990
Laura Innes, as Nora Diamond, July 4 - 18, 1988
Michael Jeter, as Arnie Gallo, September 15, 1988 - October 24, 1988 [recur]
Jane Krakowski, as Tanya Tabotchnik, Sam Fowler's date, February 15 and 16, 1989
Eriq LaSalle, as Carl, Julie Ann Edwards' date, January 15, 1987
Matt Lauer, as a gallery patron, October 27, 1982
Ray Liotta, as Joey Perrini, April 4, 1978 - November 9, 1981
Lindsay Lohan, as Alli Fowler, December 25, 1996 - July 1, 1997
William H. Macy, as Frank Fish, April - June 1982
Wendie Malick, as Cecile DePoulignac's henchwoman, May 6, 1986
Marla Maples, as Jason Frame's date, one episode, 1988
John C. McGinley, as Ned Barry, Vicky Hudson's ex-flame, September 2, 1985 - June 19, 1986
Michael McGlone, as Andy Mason, a patient of John Hudson's who received severe burns from combat in "Operation Desert Storm," November 29, 1991
Debra Messing, as Daisy, a mid-wife interviewed by Cass Winthrop and Frankie Frame, August 13, 1993
Natalija Nogulich, as a saleswoman at a jewerly store, January 29, 1988
Chris Noth, as (1) Jimmy, June 12 - August 12, 1985 [recur], and (2) Dean Whitney, February 9, 1988
Ed O'Neill, as Lenny, Ilsa Fredericks' henchman, July 7 - August 14, 1981
Joe Pantoliano, as a process server, 1977
Luke Perry, as Kenny Reed, Josie Watt's manager and one of the two Frame borders, December 1, 1988 - February 21, 1989
Christina Pickles, as Elena DePoulignac, July 6, 1977 - July 31, 1979
Brad Pitt, as Chris, a high school student in a location shot with Michael and John Hudson, May 14 and 15, 1987
Ving Rhames, as Czaja Carnek, henchman of Cecile DePoulignac, May 14 - August 5, 1986
Kelly Rowan, as Suzie Strathmore, August 11, 1988
Tom Everett Scott, as Jack, a man accosted by Ian Rain at The Surf Bar, August 21, 1994
Kyra Sedgwick, as Julia Shearer, January 15, 1982 - June 2, 1983
Ben Shenkman, as Dr. Lane, a surgeon who offends Morgan Winthrop by insulting a deceased Kyle Barkely, February 8, 1994
Ann Sheridan, as Katherine Corning, November 9, 1965 - April 15, 1966
Jean Smart, as a bus passenger, who briefly interacted with Sandy Cory on his way to Santa Monica, California, August 31, 1981
Helen Slater, as Suzie, an ex-flame of Pete Shea's who made Diana Frame jealous, February 1982
John Spencer, as Frank Julian, July 27, 1988
Susan Sullivan, as Lenore Moore, May 21, 1971 - June 24, 1975; December 22 - 29, 1975
Janine Turner, as Patricia Kirkland, an old girlfriend of Scott LsSalle's, recurring, December 23, 1986 - March 24, 1987
Dylan Walsh, as an orderly, who briefly interacted with Reginald Love and John Hudson, September 4, 1987
Paul Wasilewski (Wesley), as Sean McKinnon, May 28 - June 25, 1999
Billy Dee Williams, as the Assistant D.A. Ted Marsh, May 8 - June 27, 1967
B.D. Wong, as Lily Tran's suitor from Vietnam, September 22, 1992
Henry Winkler, as (1) an intern, June 20, 1972, and (2) Postman, who delivered Alice Matthews Frame's letter to Jim and Mary Matthews, September 27, 1972
Bellamy Young, as Dr. Courtney Evans, July 18, 1995
Rick Yune, as Assistant District Attorney to Dana Kramer during Nick Hudson's trial, July 30, 1997